I've been bit a couple times thinking that cloning a machine using Backup Exec System Recovery would give me an exact copy. This is probably the case if you do a straight recovery on the same hardware but when you recover checking off the option that this is different hardware, you get a minisetup from microsoft on first boot so that it can find and load the new device drivers.
I couple of things different on these clones that I've found:
1. If you had any secondary IP addresses on the network card, you need to re-add them
2. If you Data Execution Protection settings, they appeared to be changed. I had to re-add the applications that were listed before cloning.